Biologic behavior of adenoid cystic carcinoma of major salivary glands

Czech version

Authors: M. Hyravý ¹; I. Stárek ¹; Richard Salzman ¹ ; P. Beláková ¹ ; V. Kubec ²; L. Hauer ³
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku, Lékařská fakulta, Univerzita Palackého v Olomouci, Fakultní nemocnice Olomouc ¹; Otorinolaryngologická klinika, Lékařská fakulta v Plzni, Univerzita Karlova, Fakultní nemocnice Plzeň ²; Stomatologická klinika, Lékařská fakulta v Plzni, Univerzita Karlova, Fakultní nemocnice Plzeň ³
Published in: Otorinolaryngol Foniatr, 69, 2020, No. 4, pp. 151-157.
Category: Original Article

Overview

Introduction: Adenoid cystic carcinoma (AdCC) is a slowly growing tumor for which recurrences and distant metastases are common. It is one of the most frequent salivary malignancies and accounts for 5% of these tumours. Most of clinical studies collect minor and major salivary gland tumours, but just a few focus on the latter.

Methods: In our retrospective study we investigate biological behaviour and survival of 32 patients with AdCC of major salivary gland treated on 3 clinics – University hospital Olomouc and University hospital Plzeň between 1989–2014.

Results: The 5-year, 10-year and 15-year overall survival (OS) in the cohort were 79.8%, 75.8% and 57.8% respectively. For low stage tumours (stage I + II) OS were at 5,10 and 15 years the same – 87.5%, while for stage III + IV were 70.7%, 62.9% and 31.4%, respectively. Corresponding disease specific survival (DSS) and disease free survival (DFS) in local limited disease has reached 96.0%, 91.2% and 69.5%, and 79.0%, 69.0% and 30.7%. During the same time interval we achieved local control in 85.9%, 75.4% and 60.3%, respectively, while distant metastases incidence increased from 10.4% to 24.4% and 48.2%.

Conclusion: Our results confirm difficult control of advanced stages of AdCC and are consistent with previous studies. Therefore lifelong follow-up is advised.

Keywords:

adenoid cystic carcinoma – oncology – salivary glands

Sources

1. Adelstein, D. J., Koyfman, S. A., El-Naggar, A. K., et al.: Biology and management of salivary gland cancers. Semin Radiat Oncol, 22, 2012, 3, s. 245–253.

2. Amit, M., Binenbaum, Y., Trejo-Leider, L., et al.: International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck. Head Neck, 37, 2015, 7, s. 1038–1045.

3. Barrett, A. W., Speight, P. M.: Perineural invasion in adenoid cystic carcinoma of salivary glands: A valid prognostic indicator? Oral Oncol, 45, 2009, 11, s. 936–940.

4. Billroth, C. A.: Untersuchungen über die Entwicklung der Blutgefässe. Berlin: Reiner, 1856.

5. Bjørndal, K., Krogdahl, A., Therkildsen, M. H., et al.: Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA). Oral Oncol, 47, 2011, 7, s. 677–682.

6. Bradley, P. J.: Adenoid cystic carcinoma evaluation and management: progress with optimism! Curr Opin Otolaryngol Head Neck Surg, 25, 2017, 2, s. 147–153.

7. Brož, M., Šteiner, P., Salzman, R., et al.: The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary gland and its prognostic signifikance. Biomed Pap Med Univ Palacky Olomouc Czech Repub, 160, 2016, 3, s. 417–422.

8. Ciccolallo, L., Licitra, L., Cantú, G., et al.: Survival from salivary glands adenoid cystic carcinoma in European populations. Oral Oncol, 45, 2009, 8, s. 669–674.

9. Coca-Pelaz, A., Rodrigo, J. P., Bradley, P. J., et al.: Adenoid cystic carcinoma of the head and neck – An update. Oral Oncol, 51, 2015, 7, s. 652–661.

10. De Berardinis, R., Viziano, A., Micarelli, A., et al.: Adenoid cystic carcinoma of head and neck. Am J Otolaryngol Head and Neck, 1, 2018, 2, s. 1010.

11. Ellington, C. L., Goodman, M., Kono, S. A., et al.: Adenoid cystic carcinoma of the head and neck. Cancer, 118, 2012, 18, s. 4444–4451.

12. Fordice, J., Kershaw, C., El-Naggar, A., et al.: Adenoid cystic carcinoma of the head and neck: predictors of morbidity and mortality. Arch Otolaryngol Head Neck Surg, 125, 1999, 2, s. 149–152.

13. Garden, A. S., Weber, R. S., Morrison, W. H., et al.: The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation. Int J Radiat Oncol Biol Phys, 32, 1995, 3, s. 619–626.

14. Gurney, T. A., Eisele, D. W., Weinberg, V., et al.: Adenoid cystic carcinoma of the major salivary glands treated with surgery and radiation. Laryngoscope, 115, 2005, 7, s. 1278–1282.

15. Guzzo, M., Locati, L. D., Prott, F. J., et al: Major and minor salivary gland tumors. Crit Rev Oncol Hematol, 74, 2010, 2, s. 134–148.

16. Harada, K., Ferdous, T., Ueyama, Y.: PD-L1 expression in malignant salivary gland tumors. BMC Cancer, 18, 2018, art. 156.

17. Hauer, L., Skálová, A., Šteiner, P., et al.: Adenoidně cystický karcinom slinných žláz. Soubor 27 pacientů. Čes Stomatol Prakt Zubní Lek, 116, 2016, 3, s. 57–65.

18. Hutcheson, J. A., Vural, E., Korourian, S., et al: Neural cell adhesion molecule expression in adenoid cystic carcinoma of the head and neck. Laryngoscope, 110, 2000, 6, s. 946–948.

19. Chauhan, D. S., Guruprasad, Y.: Dermal cylindroma of the scalp. Nat J Maxillofac Surg, 3, 2012, 1, s. 59–61.

20. Chen, A. M., Bucci, M. K., Weinberg, V., et al.: Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: prognostic features of recurrence. Int J Radiat Oncol Biol Phys, 66, 2006, 1, s. 152–159.

21. Chintakuntlawar, A. V., Okuno, S. H., Price, K. A.: Systemic therapy for recurrent or metastatic salivary gland malignancies. Cancers Head Neck, 11, 2016, 1, Dostupné z: doi: 10.1186/s41199-016-0011-z.

22. Jang, J. Y., Choi, N., Ko, Y. H., et al.: Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1-2 N0 high-grade salivary gland cancer. BMC Cancer, 18, 2018, 1, s. 672.

23. Li, N., Xu, L., Zhao, H., et al.: A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. Cancer, 118, 2012, 16, s. 3945–3953.

24. Lorain, M., Robin, C.: Des tumeurs heteradeniques. C R Soc Biol, 6, 1854, s. 209–221.

25. Megwalu, U. C., Sirjani, D.: Risk of nodal metastasis in major salivary gland adenoid cystic carcinoma. Otolaryngol Head Neck Surg, 156, 2017, 4, s. 660–664.

26. Mendenhall, W. M., Morris, C. G., Amdur, R. J., et al.: Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck. Head Neck, 26, 2004, 2, s. 154–162.

27. Myers, E. N., Ferris, R. L.: Salivary gland disorders. 1st ed. Berlin: Springer-Verlag, 2007, s. 59–62.

28. Nagao, T.: Dedifferentiation and high-grade transformation in salivary gland carcinomas. Head and Neck Pathol, 7, 2013, s. 37–47.

29. NCCN clinical practice guidelines in oncology, Head and neck cancers, Salivary gland tumors, Dostupné z: www.nccn.org

30. Ning, C., Zhao, T., Wang, Z., Li, D., et al.: Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis. Cancer Manag Res, 10, 2018, s. 1677–1685.

31. Oplatek, A., Ozer, E., Agrawal, A., et al.: Patterns of recurrence and survival of head and neck adenoid cystic carcinoma after definitive resection. Laryngoscope, 120, 2010, 1, s. 65–70.

32. Ouyang, D. Q., Liang, L. Z., Zheng, G. S., et al.: Risk factors and prognosis for salivary gland adenoid cystic carcinoma in southern China: A 25-year retrospective study. Medicine, 96, 2017, 5, art. e5964.

33. Robin, C., Laboulbene, A.: Memoire sur trois productions morbides non decrites. C R Soc Biol, 5, 1853, s. 185–196.

34. Seethala, R. R., Hunt, J. L., Baloch, Z. W., et al.: Adenoid cystic carcinoma with high-grade transformation a report of 11 cases and a review of the literature. Am J Surg Pathol, 31, 2007, 11, s. 1683–1694.

35. Seethala, R. R.: An update on grading o salivary gland carcinomas. Head Neck Pathol, 3, 2009, 1, s. 69–77.

36. Sentani, K., Ogawa, I., Ozasa, K., et al.: Characteristics of 5015 salivary gland neoplasms registered in the Hiroshima tumor tissue registry over a period of 39 years. J Clin Med, 8, 2019, 5, art. 566.

37. Shah, K., Javed, F., Alcock, C., et al.: Parotid cancer treatment with surgery followed by radiotherapy in Oxford over 15 years. Ann R Coll Surg Engl, 93, 2011, 3, s. 218–222.

38. Simpson, R., H., Skálová, A., Di Palma, S., et al.: Recent advances in the diagnostic pathology of salivary carcinomas. Virchows Arch, 465, 2014, 4, s. 371–384.

39. Smith, T. L., Bryant, C. M., Bradley, J. A., et al.: Outcomes after proton therapy for salivary gland cancer.Int J Radiat Oncol Biol Phys, 93, 2015, 3, s. 320–321.

40. Spies, J. W.: Adenoid cystic carcinoma. Arch Surg, 21, 1930, s. 365–404.

41. Spiro, R. H., Thaler, H. T., Hicks, W. F., et al.: The importance of clinical staging of minor salivary gland carcinoma. Am J Surg, 162, 1991, 4, s. 330–336.

42. Spiro, R. H., Huvos, A. G.: Stage means more than grade in adenoid cystic carcinoma. Am J Surg, 164, 1992, 6, s. 623–628.

43. Stárek, I., Salzman, R., Kučerová. L., et al.: Expression of VEGF-C/-D and lymphangiogenesis in salivary adenoid cystic carcinoma. Pathol Res Pract, 211, 2015, 10, s. 759–765.

44. Stárek, I., Salzman, R., Skálová, A., et al.: Doporučené postupy v diagnostice a léčbě nádorů příušní žlázy. Otorinolaryngol Foniatr, 66, 2017, 3, s. 119–126.

45. Szanto, P. A., Luna, M. A., Tortoledo, M. E., et al.: Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer, 54, 1984, 6, s. 1062–1069.

46. Šteiner, P., Andreasen, S., Grossmann, P., et al.: Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands. Virchows Arch, 473, 2018, 4, s. 471–480.

47. Šteiner, P., Pavelka, J., Vaněček, T., et al.: Metody detekce molekulárních prognostických a prediktivních markerů v diagnostice adenoidně cystického karcinomu slinných žláz. Cesk Patol, 54, 2018, 3, s. 132–136.

48. Umeda, M., Nishimatsu, N., Masago, H., et al.: Tumor-doubling time and onset of pulmonary metastasis from adenoid cystic carcinoma of the salivary gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 88, 1999, 4, s. 473–478.