Pyoderma Gangrenosum as a Sign of Extraintestinal Manifestation of Crohn Disease in ENT Region
Authors:
R. Černý 1; T. Pniak 2; Pavel Komínek 2
; I. Krč 3
Authors‘ workplace:
H. N. O. Zentrum, Rheinstrasse 7, Darmstadt, SRN
Otorinolaryngologická klinika FN Ostrava
1; přednosta doc. MUDr. P. Komínek, Ph. D., MBA
2. interní klinika FN Olomouc
2; přednosta doc. MUDr. V. Procházka, Ph. D.
3
Published in:
Otorinolaryngol Foniatr, 58, 2009, No. 3, pp. 156-159.
Category:
Case History
Overview
Pyoderma gangrenosum, which is a dermatologic extraintestinal manifestation of Crohn disease and ulcerative colitis, is quite rare in ENT region.
A case of 48-year old female patient, suffering from Crohn disease is presented. She has repeatedly undertaken biopsy from a whitish infiltration of right tonsil and palate. No signs of malignant tumor were detected. After few weeks, complete remission of mucosal lesion was observed. However, 4 months later we have noticed pyoderma gangrenosum of nasal area with perforation to oral cavity. Later, malignant outbreak of T/NK - cell lymphoma leading to death of a patient occurred.
Key words:
pyoderma gangrenosum, Crohn disease, extraintestinal manifestations.
Sources
1. Ahmad, J., Owens, D.: Granulomatous cheilitis in Crohn disease. Canad. J. Gastroenterol., 15, 2001, s. 273-275.
2. Akbayir, N., Celis, A., Alkim, C. et al.: Sensorineural hearing loss in patients with inflammatory bowel disease. Digest. Dis. Science., 50, 2005, s. 1938-1945.
3. Bachmeyer, C., Leclere-Landgraf, N., Laureáte, F. et al.: Acute autoimmune sensorineural hearing loss associates with Crohn disease. Amer. J. Gastroenterol., 93, 1998, s. 2565-2567.
4. Griga T.: Cutaneus manifestation in inflammatory bowel diseases. Z. gastroenterol., 39, 2001, S. 137-144.
5. Husová, L., Husa, P., Berger, R. et al.: Atypická lokalizace pyoderma gangrenosum u pacienta s ulcerativní kolitidou. Vnitř. Lék., 51, 2005, s. 1400-1405.
6. Krikowich M., Kelly S., Jacson W.: Nasal septal perforation. Ear Nose Throat J., 79, 2000, s. 520-523.
7. Lopez, R., Roman, A., Bermejo, F. et al.: Pyoderma gangrenosum associated with ulcerative colitis. Rev. Esp. Enfermed. Digest., 96, 2004, s. 420-424.
8. Lukáš, M.: Perspektivy biologické léčby u Crohnovy nemoci a ulcerozní kolitidy. Lék. Listy, 2, 2008, s. 3-5.
9. Mařatka, Z.: Gastroenterologie. Nakl. Karolinum, Praha, 1999, s. 490.
10. Repiso, A., Alcantara, M., Muňos-Posas, C. et al.: Extraintestinal manifestations of Crohn disease. Rev. Esp. Enfermed. Digest., 98, 2006, s. 510-517.
11. Tromm, A., May, D., Voigt, E. et al.: Cutaneus manifestations in inflammatory bowel diseases. Gastroenterol., 39, 2001, s. 137-144.
12. Van der Scheuer, M., van der Waal, R., van Bodegraven, A.: Cheilitis granulomatosa and optic neuropathy as a extraintestinal manifestation of crohn disease. J. Clin. Gastroenterol., 34, 2002, s. 557-559.
13. Targan, S., Feagan, B., Fedorek, R. et al.: Natalizumab for the treatement of Active Crohn Disease. Gastroenterol., 132, 2007, s. 1672-1683.
14. Travis, S., Innes, N., Davies, G. et al.: Sweets syndrome: an unusual cutaneus feature of Crohn disease or ulcerative colitis. Eur. J. Gastroenterol. Hepatol., 9, 1997, s. 715-720.
15. Vaz, A., Kamer, K., Kalish, R.: Sweets syndrome in association with Crohn Disease. Postgrad. Med. J., 76, 2000, s. 713-714.
16. Zarrinneshan, A., Zapanta, P., Wall, S.: Nasal septal pyogenic granuloma. Otolaryng. Head Neck Surg., 136, 2007, s. 130-131.
Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)Article was published in
Otorhinolaryngology and Phoniatrics
2009 Issue 3
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