Intranasal Administration of Lactobacillus Acidophilus in Children

Czech version

Authors: Z. Kabelka ¹; D. Kolešková ¹; Z. Krylová ¹; A. Šalaková ²; V. Dráb ²; O. Nyč ³; V. Klemensová ³
Authors‘ workplace: Klinika ORL 2. LF UK a FN Motol, Praha ¹; Výzkumný ústav mlékárenský, s. r. o., Praha ²; Ústav lékařské imunologie 2. LF UK a FN Motol, Praha ³
Published in: Otorinolaryngol Foniatr, 62, 2013, No. 2, pp. 84-88.
Category: Original Article

Overview

Usefulness of probiotics in prevention and treatment of non-microbial disorders is studied for a long time. Intranasal and nasopharyngeal application was not published yet. We have studied application in children after check-out of it in adult volunteers. In 16 from 18 children (0.5–13 years) suffering from acute nasopharyngeal inflammation we observed improvement of their health status without necessity of antibiotics treatment. There were no adverse reactions.

Keywords:
probiotics, Lactobacillus acidophilus, infection prevention, intranasal application

Sources

1. Ataie-Jafari, A., Larijani, B., Alavi Majd, H., Tahbaz, F.: Cholesterol-lowering effect of probiotic yogurt in comparison with ordinary yogurt in mildly to moderately hypercholesterolemic subjects. Ann Nutr. Metab., 54, 2009, s. 22-27.

2. Cannon, J. P., Lee, T. A., Bolanos, J. T., Danziger, L. H.: Pathogenic relevance of Lactobacillus: a retrospective review of over 200 cases. Eur. J. Clin. Microbiol. Infect Dis., 24, 2005, s. 31-40.

3. Cunninghem-Rundles, S., Ahrne, S., Bengmark, S., Johann-Liang, R., Marshall, F., Metakis, L., Califano, C., Dunn, A. M., Grassey, C., Hinds, G., Cervia, J.: . Probiotics and immune response. Am. J. Gastroenterol., 95, 2000, s. S22-S25.

4. Dongarrà, M. L., Rizzello, V., Muccio, L., Fries, W., Cascio, A., Bonaccorsi, I., Ferlazzo, G.: Mucosal immunology and probiotics. Abstrakt Cur. Allergy Asthma Rep., 13, 2013, s. 19-26. [Epub ahead of print].

5. Ellis, C. L., Rutledge, J. C., Underwood, M. A.: Intestinal microbiota and blue baby syndrome. Gut Microbes, 1, 2010, s. 359-366.

6. Ewaschuk, J. B., Dieleman, L. A.: Probiotics and prebiotics in chronic inflammatory bowel diseases. World J. Gastroenterol., 12, 2006, s. 5941-5950.

7. Fedorak, R. N., Madsen, K. L.: Probiotics and the management of inflammatory bowel disease. Inflamm Bowel Dis., 10, 2004, s. 286-299.

8. Friedrich, M. J.: A bit of culture for children: probiotics may improve health and fight disease. JAMA, 284, 2000, s. 1365-1366.

9. Gao X., W., Mubasher, M. Fang, C. Y., Reifer, C., Miller, L. E.: Dose-response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea prophylaxis in adult patients. Am. J. Gastroenterol., 105, 2010, s. 1636-1641.

10. Gill, H. S., Rutherford, K. J., Cross, M. L.: Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. J. Clin. Immunol., 21, 2001, s. 264-271.

11. Gill, H. S., Rutherford, K. J., Cross, M. L., Gopal, P. K.: Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am. J. Clin. Nutr., 74, 2001, s. 833-839.

12. Hatakka, K., Savilahti, E., Pönkä, A., Meurman, J. H., Poussa, T., Näse, L., Saxelin, M., Korpela, R.: Effect of long term consumption of probiotic milk on infections in children attending day care centers: double-blind, randomized trial. BMJ, 322, 2001, s. 1327.

13. Hsieh, P. S., Tsai, Y. C., Chen, Y. C., Teh, S. F., Ou, C. M., King, V. A.: Eradication of Helicobacter pylori Infection by the Probiotic Strains Lactobacillus johnsonii MH-68 and L. salivarius ssp. salicinius AP-32. Helicobacter., 17, 2012, s. 466-477.

14. Chitapanarux, I., Chitapanarus, T., Traisathit, P., Kudumpee, S., Tharavichitkul, E., Lorvidhaya, V.: Randomized controlled trial of live lactobacillus acidophilu plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients. Radiat. Oncol., 5, 2010, s. 31.

15. Ishida, Y., Nakamura, F., Kanzato, H., Sawada, D., Yamamoto, N., Kagata, H., Oh-Ida, M., Takeuchi, H., Fujiwara, S.: Effect of milk fermented with Lactobacillus acidophilus strain L-92 on symptoms of Japanese cedar pollen allergy: a randomized placebo-controlled trial. Biosci Biotechnik. Biochem., 69, 2005, s.1652-1660.

16. Kalliomaki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P., Isolauri, E.: Probiotics in primary prevention of atopic disease: a randomized placebo controlled trial. Lancet, 357, 2001, s. 1076-1079.

17. Kopp, M.V., Salfeld, P.: Probiotics and prevention of allergic disease. Review. Curr. Opin. Clin. Nutr. Metab. Care, 12, 2009, s. 298-303.

18. Leyer, G. J., Li, S., Mubasher, M. E., Reifer, C., Ouwehand, A. C.: Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics, 124, 2009, s. 172-179.

19. Martinez, R. C., Franceschini, S. A., Patta, M. C., Quintana, S. M., Candido, R. C., Ferreira, J. C., De Martinis, E. C., Reid, G.: Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Lett. Appl. Microbiol., 48, 2009, s. 269-274.

20. Mayo Clinic: Acidophilus (Lactobacillus acidophilus): stránka http://www.mayoclinic.com/health/lactobacillus/NS_patient-acidophilus.

21. McFarland, L. V.: Meta-analysis of probiotics for the prevention of traveler's diarrhea. Travel Med. Infect Dis., 5, 2007, s. 97-105.

22. Mukerji, S. S., Pynnonen, M. A., Kim, H. M., Singer, A., Tabor, M., Terrell, J. E.: Probiotics as adjunctive treatment for chronic rhinosinusitis: a randomized controlled trial. Otolaryngol. Head Neck Surg., 140, 2009, s. 202-208.

23. Reid, G.: Probiotic agents to protect the urogenital tract against infection. [Review]. Am. J. Clin. Nutr., 73, 2001, s. 437S-443S.

24. Sheih, Y. H.: Systemic immunity-enhancing effects in health subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001. J. Am. Coll. Nutr., 20, 2001, s. 149-156.

25. Singh, V., Raheja, G., Borthakur, A., Kumar, A., Gill, R. K., Alakkam, A., Malakooti, J., Dudeja, P. K.: Lactobacillus acidophilus Upregulates Intestinal NHE3 Expression and Function. Am. J. Physiol. Gastrointest Liver Physiol., 15, 2012, s 1393-1401.

26. Shakirova, L., Grube, M., Gavare, M., Auzina, L., Zikmanis, P.: Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 cell surface hydrophobicity and survival of the cells under adverse environmental conditions. J. Ind. Microbiol. Biotechnol., 40, 2013, s. 85-93.

27. Skopińska, E., Lachowicz, D., Wultańska, D., Pawłowska, J., Jedrzejewska, A., Obuch-Woszczatyński, P., Pituch, H.: Assessment of antagonistic activity in vitro Lactobacillus spp. strains againts Clostridum difficile strains isolated from gastrointestinal tract of patients hospitalized in three hospitals in region Mazovia. Abstrakt Med. Dosw. Mikrobiol., 64, 2012, s. 109-114.

28. Sugumari, E., Piranitha, J., Thamaraiselvan, M.: Bugs that debugs: Probiotics. J. Pharm. Bioallied. Sci., 4, 2012, s. S319-S322.

29. University of Maryland Medical Systemryland Medical System: Lactobacillus acidophilus

30. http://www.umm.edu/altmed/articles/lactobacillus-acidophilus-000310.htm#ixzz2AOrcFMJZ, I, 1-8.

31. Vrese, M., Marteau, P. R.: Probiotics and prebiotics: effects on diarrhea. J. Nutr., 137, 2007, s. 803S-811S.

32. Zanten, G. C., Knudsen, A., Röytiö, H., Forssten, S., Lawther, M., Blennow, A., Lahtinen, S. J., Jakobsen, M., Svensson, B., Jespersen, L.: The effect of selected synbiotics on microbial composition and short-chain Fatty Acid production in a model system of the human colon. PLoS One. 7, 2012, e47212. on line 10.1371/journal.pone.0047212.

Labels

Audiology Paediatric ENT ENT (Otorhinolaryngology)

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Article was published in

Otorhinolaryngology and Phoniatrics

2013 Issue 2