Overview of most common local complications of oncological treatment of head and neck tumors
Authors:
A. Bouřová; T. Podlešák
Authors‘ workplace:
ORL oddělení Nemocnice Na Bulovce
Published in:
Otorinolaryngol Foniatr, 69, 2020, No. 1, pp. 24-30.
Category:
Review Article
Overview
The most frequent acute complications of oncological treatment include acute mucositis and dermatitis, to some extent affecting almost all patients treated for head and neck cancer. The greatest risk of acute toxicity is the need for interruption or discontinuation of ongoing therapy, with even short-term discontinuation of treatment significantly impairing subsequent local control of the cancer. The recommendations for affecting acute symptoms are based on the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Late complications include dysphagic complaints, xerostomia, and dependence on airway tracheostomy. These complications significantly affect the quality of life of the patient and are very poorly controllable. The aim of the article is to give an overview of the most frequent local complications of oncological treatment, including the current possibilities of their therapy.
Keywords:
dysphagia – mucositis – dermatitis – xerostomy – persistent tracheostoma – osteoradionecrosis
Sources
1. Ahadian, H., Yassaei, S., Bouzarjomehri, F. et al.: Oral Complications of The Oromaxillofacial Area Radiotherapy. Asian Pac J Cancer Prev, 18, 2017, 3, s. 721–725.
2. Aschermannová, A.: Záněty dutiny ústní při nádorové léčbě, obecné informace pro pacienty. Praha, Liga proti rakovině, 2012.
3. Biswal, B. M.: Current trends in the management of oral mucositis related to cancer treatment. Malays J Med Sci, 15, 2008, 3, s. 4–13.
4. Cmelak, A. J., Li, S., Goldwasser, M. A. et al.: Phase II trial of chemoradiation for organ preservation in resectable stage III or IV squamous cell carcinomas of the larynx or oropharynx: results of Eastern Cooperative Oncology Group Study E2399. J Clin Oncol, 25, 2007, 25, s. 3971–3977.
5. Čelakovský, P., Plzák, J., Betka, J. et al.: Krční metastázy. 1. vyd., Havlíčkův Brod, TOBIÁŠ, 2012.
6. Chiesa Estomba, C. M., Betances Reinoso, F. A., Martinez Villasmil, V. et al.: Persistent Tracheostomy after Organ Preservation Protocol in Patients Treated for Larynx and Hypopharynx Cancer. Int Arch Otorhinolaryngol, 21, 2017, 4, s. 377–381.
7. Fliss, D.: Complications from radiation therapy to the head and neck, Health & Medicine, 2012. Dostupné z https://www.slideshare.net/EAFO/h-complicationsfromradiationtherapytothe-headandneck-fliss
8. Gruna, J., Dvořáčková, J., Hodan, R. et al.: Osteonekrózy čelistí u onkologicky nemocných. Remedia, 20, 2010, 5, s. 338–342.
9. Hynková, L., Doležalová, H.: Nežádoucí účinky radioterapie a podpůrná léčba u radioterapie nádorů hlavy a krku. Onkologie, 2, 2008, 2, s. 88–90.
10. Chen, L. Y., Huang, C. C., Tsou, Y. A. et al.: Prognostic factor of severe complications in patients with hypopharyngeal cancer with primary concurrent chemoradiotherapy. Anticancer Res, 35, 2015, 3, s. 1735–1741.
11. Jurišová, Z., Sýkorová, Z.: Kožní postradiační reakce. Sestra, 23, 2013, 9, s. 43–46.
12. King, S. N., Dunlap, N. E., Tennant, P. A. et al.: Pathophysiology of Radiation-Induced Dysphagia in Head and Neck Cancer. Dysphagia, 31, 2016, 3, s. 339–351.
13. Kurnatowski, P., Moqbil, S., Kaczmarczyk, D.: Signs, symptoms and the prevalence of fungi detected from the oral cavity and pharynx of radiotherapy subjects with head and neck tumors, and their susceptibility to chemotherapeutics. Ann Parasitol, 60, 2014, 3, s. 207–213.
14. Lalla, R. V., Bowen, J., Barasch, A. et al.: MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 120, 2014, 10, s. 1453–1461.
15. Lalla, R.V., Sonis, S.T., Peterson, D.E.: Management of oral mucositis in patients who have cancer. Dent Clin North Am, 52, 2008, 1, s. 61–77.
16. Leventhal, J., Young, M. R.: Radiation Dermatitis: Recognition, Prevention, and Management. Oncology (Williston Park), 31, 2017, 12, s. 885–887, 894–889.
17. Li, E., Trovato, J. A.: New developments in management of oral mucositis in patients with head and neck cancer or receiving targeted anticancer therapies. Am J Health Syst Pharm, 69, 2012, 12, s. 1031–1037.
18. Maria, O.M., Eliopoulos, N., Muanza, T.: Radiation-Induced Oral Mucositis. Front Oncol, 7, 2017, 89, s. 1–24.
19. Masarykův onkologický ústav. Diagnosticko-léčebné protokoly, poslední revize 2016. Dostupné z https://www.mou.cz/diagnosticko-lecebne-protokoly/t2085
20. Narvaez, C., Doemer, C., Idel, C. et al.: Radiotherapy related skin toxicity (RAREST-01): Mepitel(R) film versus standard care in patients with locally advanced head-and-neck cancer. BMC Cancer, 18, 2018, 1, s. 197.
21. Nutting, C. M., Morden, J. P., Harrington, K. J. et al.: Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol, 12, 2011, 2, s. 127–136.
22. Pála, M.: Léčba nádorů hlavy a krku a její komplikace, obecné informace pro pacienty, Praha, Liga proti rakovině, 2011.
23. Royik, T.: Chronické vedlejší účinky radioterapie u nádorů hlavy a krku, Brno, 2016, bakalářská práce, Masarykova univerzita, lékařská fakulta, katedra radiologických metod. Dostupné z URL: http://docplayer.cz/18105789-Masarykova-univerzita.html
24. RTOG Foundation Inc.: Cooperative Group Common Toxicity Criteria, Dostupné z www.rtog.org/ResearchAssociates/AdverseEventReporting/CooperativeGroupCommonToxicityCriteria.aspx
25. Smilek, P., Plzák, J., Klozar, J. et al.: Karcinomy dutiny ústní a hltanu. 1. vyd. Havlíčkův Brod, TOBIÁŠ, 2015.
26. Sonis, S. T.: The pathobiology of mucositis. Nat Rev Cancer, 4, 2004, 4, s. 277–284.
27. Tedla, M. et al.: Poruchy polykání. 1. vydání, Havlíčkův Brod, TOBIÁŠ, 2009
28. Tennant, P. A., Cash, E., Bumpous, J. M. et al.: Persistent tracheostomy after primary chemoradiation for advanced laryngeal or hypopharyngeal cancer. Head Neck, 36, 2014, 11, s. 1628–1633.
29. Vera-Llonch, M., Oster, G., Hagiwara, M. et al.: Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer, 106, 2006, 2, s. 329–336.
30. Vokurka, S.: Mukositida dutiny ústní u pacientů s onkologickou léčbou. Remedia, 25, 2015, 1, s. 39–42.
31. Vrána, D., Vlachová, Z., Matzenauer, M.: Klinický význam neplánovaných přerušení radioterapie, Onkologická klinika FN Olomouc, 2016. Dostupné z http://www.csfm.cz/userfiles/file/Udalosti_2016/vrana_vlachova_matzenauer.pdf
Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)Article was published in
Otorhinolaryngology and Phoniatrics
2020 Issue 1
Most read in this issue
- Perioperative complications of FEES in ENT department in the Hospital of České Budějovice, a.s., between 2000 - 2017
- Risk factor of thyroid surgery complications
- Overview of most common local complications of oncological treatment of head and neck tumors
- Neonatal hearing screening - current situation and how to proceed?