Warthin’s tumour of the nasopharynx – a case report and literature review
Authors:
Ivo Stárek 1
; Z. Horáková 1
; D. Skanderová 2
Authors‘ workplace:
Klinika otorinolaryngologie a chirurgie hlavy a krku LF UP a FN Olomouc
1; Ústav klinické a molekulární patologie LF UP a FN Olomouc
2
Published in:
Otorinolaryngol Foniatr, 72, 2023, No. 3, pp. 152-156.
Category:
Case Reports
doi:
https://doi.org/10.48095/ccorl2023152
Overview
Papillary cystic adenolymphoma, usually called Warthin’s tumour (WT), is the second most common benign salivary gland tumour with a relative incidence of up to 25%. Typically, it is localized in the parotid gland or in its proximity where it arises from salivary inclusions entrapped in the intra- and paraparotic lymph nodes. In the upper aerodigestive tract, the WT occurs very rarely. In the postnasal space, only 11 cases have been published in the literature so far. In this case, we bring a case report of a 61-year-old woman, a smoker, in whom the tumour was located at the nasopharyngeal ostium of the left Eustachian tube. Based on our case and review of relevant literature, we discuss clinical aspects of this extraordinary rare neoplasia.
Keywords:
Nasopharynx – Warthin’s tumour – head and neck neoplasms
Sources
1. Ellies M, Laskawi R, Arglebe C. Extraglandular Warthin‘s tumours: clinical evaluation and long-term follow-up. Br J Oral Maxillofac Surg 1998; 36(1): 52–53. Doi: 10.1016/ s02 66-4356(98)90 749-5.
2. Fantozzi RD, Bone RC, Fox R. Extraglandular Warthin‘s tumors. Laryngoscope 1985; 95(6): 6822688. Doi: 10.1288/ 00005537-1985060 00-00010.
3. Diaz-Segarra N, Young L, Le,vin K et al. Warthin tumor of the oropharyngeal minor salivary gland. SAGE Open Medical Case Reports 2018; 6: 1–4. Doi: 10.1177/ 2050313X18818712.
4. Kristensen S, Tveteras K, Friedmann I et al. Nasopharyngeal Warthin’s tumour. A metaplastic lesion. J Laryngol Otol 1989; 103: 616–619. Doi: 10.1017/ s0022215100109508.
5. Alsalem M, Al-Sawalmeh KM, Al-Khatib SM et al. Nasopharyngeal Warthin’s tumor presented as otitis media with effusion. J Otolaryngol ENT Res 2016; 4(3): 00099. Doi: 10.15406/ joentr.2016.04.00099.
6. Cellesi C. Adenolymfoma rinofaryngeo con fenomeni di parziale metaplasia oncocytaria. Arch De Vecchi Anat Patol 1969; 55: 665-668.
7. Griffiths AP, Dekker P. Oncocytic metaplasia of the nasopharynx or extra-parotid Warthin’s tumour? J Clin Pathol 1991; 44: 1030–1032. Doi: 10.1136/ jcp.44.12.1030.
8. Kawakami M, Ito K, Tanaka H et al. Warthin’s tumor of the nasopharynx: a case report. Auris Nasus Larynx 2004; 31(3): 293–298. Doi: 10.1016/ j.anl.2004.05.006.
9. Ory M, Eran A. Synchronous parotid and nasopharyngeal Warthin tumor. Head Neck 2016; 38(3): E71–2. Doi: 10.1002/ hed.24180.
10. Pelucchi S, Bianchini C, Ciorba A et al. Simultaneous nasopharyngeal and parotid gland Warthin’s tumour: a case report. Acta Otorhinolaryngol Ital 2015; 35(2): 129–131.
11. Low WK, Bian S. Synchronous parotid and nasopharyngeal Warthin’s tumors: first report of a case. Ear Nose Throat J 2002; 81: 839–841.
12. Rydzewski B. Warthin’s tumors with atypical location. Otolaryng Pol 1998; 52: 495–498.
13. Yeh YA, Baker LL, Wang WJ. Nasopharyngeal Warthin’s tumor. Otolaryngol Head Neck Surg 1999; 120: 942–944. Doi: 10.1016/ S0194-59 98(99)70344-X.
14. Yanez-Barraza KL, Domınguez-Malagon HR, MosquedaTaylor A et al. Synchronic nasopharyngeal and intraparotid Warthin tumors: a case report and literature review. J Clin Exp Dent 2014; 6(4): e435. Doi: 10.4317/ jced.51 441.
15. Seifert G, Bull HG, Donath K. Histologic subclassification of the cystadenolymphoma of the parotid gland. Analysis of 275 cases. Virchows Arch A Pathol Anat Histol 1980; 388(1): 13–38. Doi: 10.1007/ BF00430674.
16. Batsakis JG. Tumour of the major salivary glands. In: Tumours of the head and neck. Baltimore: Williams and Williams Co 1979: 1–75.
17. Khanchel-Lakhoua F, Nsiri E, Labbene N et al. An unusual lesion of the nasopharynx: oncocytic metaplasia. Ann Pathol 2011; 31(5): 396–398. Doi: 10.1016/ j.annpat.2011.06.005.
18. Watson C. Oncocytic metaplasia of the nasopharynx-unusual cause of secretory otitis media. J Laryngol Otol 1990; 104(1): 39–40. Doi: 10.1017/ s0022215100111740.
19. Azzopardi JG, Hou T. The genesis of adenolymphoma. J Pathol Bacteriol 1964; 88: 213–218. Doi: 10.1002/ path.1700880127.
20. Fantasia JE, Miller AS. Papillary cystadenoma lymphomatosum arising in minor salivary glands. Oral Surg Oral Med Oral Pathol 1981; 52(4): 411–416. Doi: 10.1016/ 0030-4220(81)903 40-6.
21. Allegra SR. Warthin‘s tumor: a hypersensitivity disease? Ultrastructural, light, and immunofluorescent study. Hum Pathol 1971; 2(3): 403–420. Doi: 10.1016/ s0046-8177(71)80007-2.
22. Gallo O. New insights into the pathogenesis of Warthin‘s tumour. Eur J Cancer B Oral Oncol 1995; 31B(4): 211–215. Doi: 10.1016/ 09 64-1955(95)00017-c.
23. Yao H, Lin H, Zhang P et al. CT and MRI findings of parotid Warthin’s tumors. Chin-German J Clin Oncol 2011; 10: 596–601. Doi: 10.1007/ s10330-011-0845-0.
24. Ikeda M, Motoor K, Hanazawa T et al. Warthin tumor of the parotid gland: diagnostic value of MR imaging with histopathologic correlation. AJNR Am J Neuroradiol 2004; 25(7): 1256–1262.
25. Peter Klussmann J, Wittekindt C, Florian Preuss S et al. High risk for bilateral Warthin tumor in heavy smokers – review of 185 cases. Acta Otolaryngol 2006; 126(11): 1213–1217. Doi: 10.1080/ 00016480600740605.
26. Therkildsen MH, Christensen N, Andersen LJ et al. Malignant Warthin‘s tumour: a case study. Histopathology 1992; 21(2): 167–171. Doi: 10.1111/ j.1365-2559.1992.tb00366.x.
Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)Article was published in
Otorhinolaryngology and Phoniatrics
2023 Issue 3
Most read in this issue
- Oesophageal and gastric corrosions – diagnostic and therapeutic approach
- Cervicofacial subcutaneous emphysema after routine dental hygiene procedure – a case report
- Rhinosinusitis as a complication of FESS: is antibiotic prophylaxis beneficial?
- Diagnosis of heterotopic gastric mucosa of the upper esophagus and its effect on the laryngeal mucosa