Hyaluronic acid and its importance and possibilities of use in otorhinolaryngology
Authors:
M. Jurovčík 1
; K. Novotná 1,2; J. Borský 1; P. Dytrych 1
; K. Kotaška 1
; Z. Čada 1
Authors‘ workplace:
Klinika ušní, nosní a krční 2. LF UK a FN v Motole, Praha
1; Klinika plastické chirurgie FN Královské Vinohrady, Praha
2
Published in:
Otorinolaryngol Foniatr, 72, 2023, No. 4, pp. 204-209.
Category:
Review Article
doi:
https://doi.org/10.48095/ccorl2023204
Overview
Hyaluronic acid (HA) is a linear, naturally occurring polysaccharide of high molecular weight. It is part of a number of bio logical processes, especially regulatory, anti-inflammatory, immunosuppressive or antiproliferative. It significantly binds water and participates in the maintenance of tissue viscoelasticity, in the supramolecular spatial arrangement of proteoglycans in the extracellular matrix and in the regulation of osmotic pressure, which significantly affects tissue homogeneity and its homeostatic integrity. Due to these properties, non-immunogenic HA can be used in many clinical applications. In otorhinolaryngology, the possibilities of its use are wide, especially in otology, laryngology, rhinology or in the treatment of inflammatory conditions and keloid scars. Some potential areas of use are still in the experimental stage (gene therapy).
Keywords:
Otorhinolaryngology – treatment – hyaluronic acid
Sources
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Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)Article was published in
Otorhinolaryngology and Phoniatrics
2023 Issue 4
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