Postterapeutické hodnotenie priamej endoskopickej autofluorescencie a ej použitie v enežmente liečby rakoviny hrtana

English version

Autoři: V. Kavečanský ¹; I. Čavarga ²; N. Lukán ³; P. Feciskanin ⁴; P. Bohuš ⁵
Působiště autorů: ENT Department, ORL Humenné, s. r. o., Humenné, Slovakia ¹; Department of Pneumology and Phtiseology, Medical Faculty Safarik University, Košice, Slovakia ²; th Department of Internal Medicine, Medical Faculty Safarik University, Košice, Slovakia ³; ENT Department of Eastern-Slovakian Institute of Oncology, Košice, Slovakia ⁴; Department of Pathology, Unversity Hospital, Košice, Slovakia ⁵
Vyšlo v časopise: Otorinolaryngol Foniatr, 61, 2012, No. 2, pp. 95-99.
Kategorie: Původní práce

Souhrn

Priama endoskopická autofluorescencia hrtana zlepšuje diagnostiku a ohraničenie prekanceróz a karcinómu. Cieľom tejto štúdie je posúdiť diagnostický potenciál a obmedzenia tejto diagnostickej metódy po chirurgickej liečbe a (alebo) po liečbe rádioterapiou. V retrospektívnej štúdii sme urobili 149 vyšetrení u 118 pacientov. Pacientov sme rozdelili do skupín podľa typu liečby a v prípade liečby rádioterapiou aj podľa času medzi autofluorescenčným vyšetrením a ukončením liečby rádioterapiou. Autofluorescencia bola indukovaná pomocou Xenónovej lampy s použitím filtrovaného pásoveho svetla modrej farby (vlnová dĺžka 390 - 470 nm ) a následne zaznamenaná pomocou veľmi citlivej trojčipovej CCD kamery. (DAFE systém firmy Richard Wolf, Knittlingen, Nemecko). Podozrivé ložiská boli vyšetrené direktnou mikrolaryngoskopiou a bola z nich odobratá vzorka na histologické vyšetrenie. Výsledky autofluorescencie sme porovnávali s výsledkami histologických vyšetrení. Výsledky senzitivity a špecificity endoskopickej autofluorescencie sa po liečbe výraznejšie nezmenili a sú porovnateľné s citlivosťou vyšetrenia pred liečbou. Na základe našich výsledkov by sa mohla priama endoskopická autofluorescencia používať aj po chirurgickej liečbe a rádioterapii na dispenzarizáciu pocientov s rakovinou hrtana.

Kľúčové slová:
autofluorescencia, endoskopia, rakovina hrtana, chirurgia, radioterapia.

Zdroje

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