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Prognostic and Predictive Significance of Expression of EGFR, Her2/neu and Genetic Alterations in EGFR Signaling Pathway in Spinocellular Carcinoma of Head and Neck


Authors: J. Neuwirthová 1;  P. Smilek 1;  J. Berkovcová 2;  M. Hajdúch 2 ;  J. Rottenberg 1;  R. Trojanec 2;  M. Dziechciarková 2;  R. Kostřica 1
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku LF MU a FN u sv. Anny, Brno ;  přednosta prof. MUDr. R. Kostřica, CSc. Laboratoř experimentální medicíny, Dětská a onkologická klinika LF UP a FN, Olomouc 1;  přednosta doc. MUDr. M. Hajdúch, Ph. D. 2
Published in: Otorinolaryngol Foniatr, 58, 2009, No. 2, pp. 89-96.
Category: Original Article

Overview

We focused attention to the prognostic and predictive value of epidermal growth factor receptor (EGFR) expression HER2/neu expresion and some genetic alterations in an EGFR signal pathway, such as EGFR amplification, expression of variant form EGFRvIII, EGFR activating tyrosine kinase mutations and k-ras gene mutation. The aim of our study was to evaluate the occurrence of these biomarkers in the correlation with a therapeutic response and survival in patients with spinocellular head and neck cancers. This study suggests that EGFR expression have a clinical value mainly in early stages of the disease. We proved a presence of activating mutations in EGFR tyrosine kinase domain, k-ras mutation and correlation between EGFR gene amplification and receptor expression.

Key words:
epidermal growth factor, receptor head and neck cancers, tyosin kinase mutation, prodictive markers, oncology, chemoradiotherapy.


Sources

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