Evaluation of Resection Margins and Their Predictive Value in Treatment of Oral Cavity Carcinoma
Authors:
O. Bulik 1; M. Machálka 1; O. Liberda 1; J. Jarkovský 2
; R. Foltán 3; J. Kyclová 4
Authors‘ workplace:
Klinika ústní, čelistní a obličejové chirurgie LF MU a FN, Brno, přednosta doc. MUDr. M. Machálka, CSc.
1; Institut biostatistiky a analýz LF a PřF MU, Brno
2; Stomatologická klinika 1. LF UK a VFN, Praha
3; ÚPA – Patologie, FN, Brno
4
Published in:
Otorinolaryngol Foniatr, 59, 2010, No. 2, pp. 72-76.
Category:
Original Article
Overview
The evaluation of resection margins in surgical treatment of oral cavity carcinoma is an important prognostic factor. Sometimes it is difficult to perform the resection in the healthy tissue because of relatively small field of operation, presence of important anatomical structures in the region of oral cavity, and advanced stage of the oncogenic disease in most patients. The outcome of resection margin zone examination modifies individually further therapeutic procedure. Lot of studies point out both increased occurrence of relapses and overall survival outcome setback in patients with positive surgical margin with regard to the presence of tumor cells.
This paper analyses a file of 71 patients with oral cavity spinocellular carcinoma in whom the surgery was a treatment part of oncogenic disease. Either the occurrence or the tumor proximity in the resection margin was detected in 28.2 % of findings. Dates of 65 patients in total were processed with focus on local relapse occurrence during there years. In case of either positive or proximate margin a local relapse occurred in 47.4 % (9/19) of patients, in case of negative margin in local relapse occurred in 26.1 % (12/46) of patients. Positive or proximate margin occurred most frequently in category T3; upper alveolar process and palate was the most frequent localization, i.e. in 55.6 % (9/15) of patients. Expressive decrease in occurrence of local relapses was recorded in case of negative surgical margin.
Key words:
oral cavity carcinoma, surgical margin,, surgical therapy evaluation, local relapse.
Sources
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Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)Article was published in
Otorhinolaryngology and Phoniatrics
2010 Issue 2
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