New Therapeutic Procedures in Otolaryngology Using Mesenchymal Stromal Cells

Czech version

Authors: L. Školoudík ¹; Viktor Chrobok ¹ ; D. Kalfeřt ¹; Z. Kočí ^2,3,4; E. Syková ^2,3; S. Filip ⁵
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku, Fakultní nemocnice Hradec Králové, Univerzita Karlova v Praze, Lékařská fakulta v Hradci Králové ¹; Ústav experimentální medicíny Akademie věd České republiky, v. v. i. ²; Oddělení neurověd, 2. lékařská fakulta Univerzity Karlovy v Praze ³; Bioinova, s. r. o., Praha ⁴; Klinika onkologie a radioterapie, Fakultní nemocnice Hradec Králové, Univerzita Karlova v Praze, Lékařská fakulta v Hradci Králové ⁵
Published in: Otorinolaryngol Foniatr, 65, 2016, No. 2, pp. 97-101.
Category: Review Article

Overview

Multipotent mesenchymal stromal cells (MSC) are used for regeneration of injured mesenchymal tissue due to their self-renewal capacity and ability to differentiate into cells of mesenchymal tissue (bone, cartilage, muscle, fat, nerve or fibrous tissues). They regenerate various tissues through self-renewal, differentiation capacity, immune modulation and secretion of bioactive molecules. Authors present a review of MSC applications in otorhinolaryngology. The major interest is focused on phonosurgery, sensorineural deafness and reconstruction of large tissue defects with bone, cartilage or soft tissue replacement. The MSCs research in Czech otorhinolaryngology is focused on bone tissue replacement. Current point of interest is the temporal bone and treatment of bone defects after middle ear surgery.

KEYWORDS:
mesenchymal stromal cells, bone replacement, middle ear surgery

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Labels

Audiology Paediatric ENT ENT (Otorhinolaryngology)

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Article was published in

Otorhinolaryngology and Phoniatrics

2016 Issue 2