#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Inflammatory myofibroblastic tumour in otorhinolaryngology


Authors: Lucie Zeinerová 1 ;  Michal Černý 1,2 ;  Jan Laco 2,3 ;  Dědková J. 4;  Viktor Chrobok 1,2
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku, FN Hradec Králové 1;  Univerzita Karlova, LF v Hradci Králové 2;  Fingerlandův ústav patologie, FN Hradec Králové 3;  Radiologická klinika, FN Hradec Králové 4
Published in: Otorinolaryngol Foniatr, 71, 2022, No. 1, pp. 38-43.
Category: Case Reports
doi: https://doi.org/10.48095/ccorl202238

Overview

Introduction: Inflammatory myofibroblastic tumour (IMT) is a rare tumour with borderline biological behaviour composed of fibroblasts and myofibroblasts and accompanied by non-neoplastic inflammatory cells. It occurs mostly in children and young adults. The disease is most commonly seen in abdominal soft tissues (omentum, mesentery, etc.), in the lungs and also has been reported in other parts of gastrointestinal tract and other organs. In the head and neck region IMT is not so common, it may occur in larynx, trachea or nasal sinuses. The primary therapeutic approach is a complete surgical excision. Radiation, chemotherapy or biological treatment modalities are used in aggressive, non-resectable, and recurrent tumours or in case of metastases. Aims: Through a case report on a small set of patients and up-to-date information from the literature, the authors want to share knowledge about the rare diagnosis of IMT in ENT, its possible clinical manifestations, differential diagnosis and appropriate treatment. The group of patients, the case report: The paper presents patients with IMT treated at the Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Kralove in the years 2013–2020. The case of a 11-year-old boy with progressive dyspnoea caused by polypoid tracheal tumour is discussed in more detail. The tumour was removed by external surgical approach with bronchoscopy assistance. Histological examination proved an IMT. Conclusion: IMT is a rare neoplasm which must be included in the differential diagnosis of tumours of the respiratory tract, especially in children and young adults. The treatment consists of complete surgical removal and regular follow-up due to the risk of local recurrence.

Keywords:

inflammatory myofibroblastic tumour – dyspnoea in a child – tracheal tumour


Sources

1. Andrade NN, Mathai PC, Kamil R et al. Inflammatory myofibroblastic tumour: A case report and a clinical update. J Oral Biol Craniofac Res 2017; 7 (3): 219–222. Doi: 10.1016/j.jobcr.2017.09.005.

2. Coffin CM, Watterson J, Priest JR et al. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995; 19 (8): 859–872. Doi: 10.1097/00000478-199508000-00001.

3. Findik S, Altinok T. Inflammatory myofibroblastic tumor of the trachea: A case report and review of the literature. J Lung Pulm Respir Res 2017; 4 (5): 000144. Doi: 10.15406/jlprr.2017.04.00 144.

4. Ozgul MA, Toru U, Acat M et al. A rare tumor of trachea: Inflammatory myofibroblastic tumor dia­gnosis and endoscopic treatment. Respir Med Case Rep 2014; 13: 57–60. Doi: 10.1016/j.rmcr.2014.10.001.

5. Palaskar S, Koshti S, Maralingannavar M et al. Inflammatory myofibroblastic tumor. Contemp Clin Dent 2011; 2 (4): 274–277. Doi: 10.4103/0976-237X.91787.

6. Souza FTA, Siqueira EC, Trajano VCC et al. Inflammatory myofibroblastic tumor in the retromolar region of mandible: a case report and literature review. J Oral Diag 2017; 2 (1): 1–6. Doi: 10.5935/2525-5711.20170015.

7. Tao J, Zhou M-L, Zhou S-H. Inflammatory myo­fibroblastic tumors of the head and nec. Int J Clin Exp Med 2015; 8 (2): 1604–1610.

8. Tay SY, Balakrishnan A. Laryngeal inflammatory myofibroblastic tumor (IMT): a case report and review of the literature. J Med Case Rep 2016; 10 (1): 180. Doi: 10.1186/s13256-016- 0967-7.

9. Volker HU, Scheich M, Holler S et al. Differential dia­gnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor--report of two cases with similar morphology. Dia­gn Pathol 2007; 2: 1. Doi: 10.1186/1746-15 96-2-1.

10. WHO Classification of Tumours Editorial Board. Soft Tissue and Bone Tumours. WHO Classification of Tumours, vol. 3. 5 ed. France: International Agency of Research on Cancer 2020.

11. Camela F, Gallucci M, di Palmo E et al. Pulmonary inflammatory myofibroblastic tumor in children: A case report and brief review of literature. Front Pediatr 2018; 6: 35. Doi: 10.3389/fped.2018.00035.

12. Myer CM, 3rd, O‘Connor DM, Cotton RT. Proposed grading system for subglottic stenosis based on endotracheal tube sizes. Ann Otol Rhinol Laryngol 1994; 103 (4 Pt 1): 319–323. Doi: 10.1177/000348949410300410.

Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)

Article was published in

Otorhinolaryngology and Phoniatrics

Issue 1

2022 Issue 1

Most read in this issue
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#