Thrombosis of cerebral vessels as a primary manifestation of parathyroid adenoma

Czech version

Authors: K. Mamiňák ^1,2 ; Ľ. Michnová ³ ; Tomáš Tyll ⁴ ; J. Astl ^1,2
Authors‘ workplace: Klinika otorinolaryngologie a maxilofaciální chirurgie 3. LF UK a ÚVN Praha ¹; 3. lékařská fakulta, Univerzita Karlova, Praha ²; Oddělení patologie, ÚVN Praha ³; Klinika anesteziologie, resuscitace a intenzivní medicíny 1. LF UK a ÚVN – VFN Praha ⁴
Published in: Otorinolaryngol Foniatr, 73, 2024, No. 3, pp. 197-202.
Category: Case Reports
doi: https://doi.org/10.48095/ccorl2024197

Overview

Primary hyperparathyroidism (HPPT) is a generalized disorder of calcium-phosphate metabolism resulting from long-term secretion of parathyroid hormone (PTH). The most common cause of PTH overproduction is an adenoma of one or more parathyroid glands. Cerebral venous sinus thrombosis accounts for about 1–2% of cerebral events and its consequence can be focal ischemia with intracerebral hemorrhage. In this article, we describe a unique case report of a patient who was urgently admitted for the progression of a sudden speech disorder and progressive impairment of consciousness on the basis of thrombosis in the cerebral sinuses and intracerebral hemorrhage. Secondary findings at the initial diagnostic process were hypophosphatemia and hypercalcemia with parathyroid hormone elevation.

Keywords:

hyperparathyroidism – hypercalcemia – cerebral venous sinus thrombosis

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ORCID autorů

K. Mamiňák 0000-0002-3935-5891,

Ľ. Michnová 0000-0002-7641-2808,

T. Tyll 0000-0003-4000-3495,

J. Astl 0000-0002-8022-0200.

Přijato k recenzi: 28. 8. 2023

Přijato k tisku: 2. 10. 2023

MUDr. Kristýna Mamiňák

Klinika otorinolaryngologie a maxilofaciální chirurgie

3. LF UK a ÚVN Praha

U Vojenské nemocnice 1200

169 02 Praha 6